Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

ABSTRACT:

Objective

To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs.

Methods

We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed.

Results

We report an association between a rare variant in the complement factor H-related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 × 10^-11; odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkag

SUBMITTER: McCormack M 

PROVIDER: S-EPMC5798660 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature