Modelling the large-scale yellow fever outbreak in Luanda, Angola, and the impact of vaccination.

ABSTRACT:

Background

Yellow fever (YF), transmitted via bites of infected mosquitoes, is a life-threatening viral disease endemic to tropical and subtropical regions of Africa and South America. YF has largely been controlled by widespread national vaccination campaigns. Nevertheless, between December 2015 and August 2016, YF resurged in Angola, quickly spread and became the largest YF outbreak for the last 30 years. Recently, YF resurged again in Brazil (December 2016). Thus, there is an urgent need to gain better understanding of the transmission pattern of YF.

Model

The present study provides a refined mathematical model, combined with modern likelihood-based statistical inference techniques, to assess and reconstruct important epidemiological processes underlying Angola's YF outbr

SUBMITTER: Zhao S 

PROVIDER: S-EPMC5798855 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature