Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.

ABSTRACT: With the recent advent of immunotherapy, there is a critical need to understand immune cell interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts. Multidimensional datasets have enabled systematic approaches to dissect these interactions in large numbers of patients, furthering our understanding of the patient immune response to solid tumors. Using an integrated approach, we inferred the infiltration levels of distinct immune cell subsets in 23 tumor types from The Cancer Genome Atlas. From these quantities, we constructed a coinfiltration network, revealing interactions between cytolytic cells and myeloid cells in the tumor microenvironment. By integrating patient mutation data, we found that while mutation burden was associated with immune infiltratio

SUBMITTER: Varn FS 

PROVIDER: S-EPMC5798883 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature