Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.

ABSTRACT:

Objective

Inflammatory response plays an important role in Parkinson disease (PD). Previous studies have reported an association between human leukocyte antigen (HLA)-DRB1 and the risk of PD. There has also been growing interest in investigating whether inflammation-related genes interact with environmental factors such as smoking to influence PD risk. We performed a pooled analysis of the interaction between HLA-DRB1 and smoking in PD in 3 population-based case-control studies from Denmark and France.

Methods

We included 2,056 cases and 2,723 controls from 3 PD studies (Denmark, France) that obtained information on smoking through interviews. Genotyping of the rs660895 polymorphism in the HLA-DRB1 region was based on saliva or blood DNA samples. To assess interactions, we u

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC5798887 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature