Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans.

ABSTRACT:

Background

Cognitive impairment is a major health concern among older Mexican Americans, associated with significant morbidity and mortality, and may be influenced by environmental exposures.

Objectives

To investigate whether agricultural based ambient organophosphorus (OP) exposure influences 1) the rate of cognitive decline and mortality and 2) whether these associations are mediated through metabolic or inflammatory biomarkers.

Methods

In a subset of older Mexican Americans from the Sacramento Area Latino Study on Aging (n = 430), who completed modified mini-mental state exams (3MSE) up to 7 times (1998-2007), we examined the relationship between estimated ambient OP exposures and cognitive decline (linear repeated measures model) and time to dementia or being cogn

SUBMITTER: Paul KC 

PROVIDER: S-EPMC5798900 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature