TRPA1 polymorphisms in chronic and complete spinal cord injury patients with neuropathic pain: a pilot study.

ABSTRACT:

Study design

Pilot study.

Objectives

Single-nucleotide polymorphisms (SNPs) in TRPA1 gene are related to the etiology of chronic pain. The study is a pilot study with the primary objective of analyzing these SNPs in Spanish patients with chronic and complete spinal cord injury (SCI) and neuropathic pain (NPP).

Setting

Asepeyo Hospital Department of Chronic and Complete SCI.

Methods

Twelve patients with chronic and complete SCI and NPP, and 12 patients with chronic and complete SCI with no pain were reviewed. International Spinal Cord Injury Pain Classification (LANSS) and visual analog score (VAS) were chosen to classify pain syndrome. SNPs were identified by melting analysis after DNA amplification with real-time fluorescence PCR.

Results

There were dif

SUBMITTER: Vidal Rodriguez S 

PROVIDER: S-EPMC5798909 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature