Activity-induced Ca²⁺ signaling in perisynaptic Schwann cells of the early postnatal mouse is mediated by P2Y₁ receptors and regulates muscle fatigue.

ABSTRACT: Perisynaptic glial cells respond to neural activity by increasing cytosolic calcium, but the significance of this pathway is unclear. Terminal/perisynaptic Schwann cells (TPSCs) are a perisynaptic glial cell at the neuromuscular junction that respond to nerve-derived substances such as acetylcholine and purines. Here, we provide genetic evidence that activity-induced calcium accumulation in neonatal TPSCs is mediated exclusively by one subtype of metabotropic purinergic receptor. In P2ry1 mutant mice lacking these responses, postsynaptic, rather than presynaptic, function was altered in response to nerve stimulation. This impairment was correlated with a greater susceptibility to activity-induced muscle fatigue. Interestingly, fatigue in P2ry1 mutants was more greatly exacerb

SUBMITTER: Heredia DJ 

PROVIDER: S-EPMC5798932 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature