Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation.

ABSTRACT: The expression patterns of endogenous circular RNA (circRNA) molecules during epidermal stem cell (EpSC) differentiation have not previously been explored. Here, we show that circRNAs are abundantly expressed in EpSCs and that their expression change dramatically during differentiation in a coordinated manner. Overall, circRNAs are expressed at higher levels in the differentiated cells, and many upregulated circRNAs are derived from developmental genes, including four different circRNAs from DLG1. The observed changes in circRNA expression were largely independent of host gene expression, and circRNAs independently upregulated upon differentiation are more prone to AGO2 binding and have more predicted miRNA binding sites compared to stably expressed circRNAs. In particular, upregulated cir

SUBMITTER: Kristensen LS 

PROVIDER: S-EPMC5798954 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature