APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals.

ABSTRACT:

Background

Cognitive training may contribute to the ability to maintain cognitive function in healthy elderly adults. Whether genotype modifies training effects remains unknown.

Objective

Assess influence of APOE on cognitive function over time in community-dwelling elderly adults participating in multi-domain cognitive training.

Methods

Healthy individuals ≥70 years of age were screened from one urban community in Shanghai. 145 healthy Chinese older adults met inclusion criteria and were assigned to intervention (n = 88) or control (n = 57) groups. Multi-domain cognitive training involved 24 sessions of different content taking place over 12 weeks. Neuropsychological testing was administered at baseline, immediately after training, six months and twelve months post-i

SUBMITTER: Feng W 

PROVIDER: S-EPMC5799000 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature