Detect, correct, retract: How to manage incorrect structural models.

ABSTRACT: The massive technical and computational progress of biomolecular crystallography has generated some adverse side effects. Most crystal structure models, produced by crystallographers or well-trained structural biologists, constitute useful sources of information, but occasional extreme outliers remind us that the process of structure determination is not fail-safe. The occurrence of severe errors or gross misinterpretations raises fundamental questions: Why do such aberrations emerge in the first place? How did they evade the sophisticated validation procedures which often produce clear and dire warnings, and why were severe errors not noticed by the depositors themselves, their supervisors, referees and editors? Once detected, what can be done to either correct, improve or eliminate such

SUBMITTER: Wlodawer A 

PROVIDER: S-EPMC5799025 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature