Ontology highlight
ABSTRACT:
SUBMITTER: Pellinen T
PROVIDER: S-EPMC5799174 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20180205 1
Caveolin-1 (CAV1) is over-expressed in prostate cancer (PCa) and is associated with adverse prognosis, but the molecular mechanisms linking CAV1 expression to disease progression are poorly understood. Extensive gene expression correlation analysis, quantitative multiplex imaging of clinical samples, and analysis of the CAV1-dependent transcriptome, supported that CAV1 re-programmes TGFβ signalling from tumour suppressive to oncogenic (i.e. induction of SLUG, PAI-1 and suppression of CDH1, DSP, ...[more]