Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells.

ABSTRACT: Macrophage migration inhibitory factor (MIF) is a non-canonical cytokine that is involved in multiple inflammatory diseases, including atherosclerosis. High MIF expression found in leukocytes which facilitates the initiation and progression of atherosclerosis. However, little is known about biomechanical forces in the induction of MIF in endothelial cells (ECs). Here, we show that laminar shear stress (LS) inhibits the expression of MIF in ECs. By profiling the whole transcriptome of human coronary artery ECs under different shear stress, we found that athero-protective LS attenuates the expression of MIF whereas pro-atherosclerotic oscillatory shear stress (OS) significantly increased the expression of MIF. En face staining of rabbit aorta revealed high MIF immunoreactivity in lesser curv

SUBMITTER: Qiao C 

PROVIDER: S-EPMC5799263 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature