Sun Exposure across the Life Course Significantly Modulates Early Multiple Sclerosis Clinical Course.

ABSTRACT:

Background

Low vitamin D and/or sun exposure have been associated with increased risk of multiple sclerosis (MS) onset. However, comparatively, few studies have prospectively examined associations between these factors and clinical course.

Objectives

To evaluate the association of sun exposure parameters and vitamin D levels with conversion to MS and relapse risk in a prospectively monitored cohort of 145 participants followed after a first demyelinating event up to 5-year review (AusLong Study).

Methods

Sun exposure prior to and after onset measured by annual questionnaire; ultraviolet radiation (UVR) "load" estimated by location of residence over the life course and ambient UVR levels. Serum 25-hydroxyvitamin D [25(OH)D] concentrations measured at baseline, 2/3-year

SUBMITTER: Simpson S 

PROVIDER: S-EPMC5799286 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature