Polymorphism in the serotonin transporter protein gene in Maltese dogs with degenerative mitral valve disease.

ABSTRACT: Degenerative mitral valve disease (DMVD) is the most commonly acquired cardiac disease in dogs. This study evaluated the relationship between genetic variations in the serotonin transporter (SERT) gene of Maltese dogs and DMVD. Genomic DNA was extracted from blood samples collected from 20 client-owned DMVD Maltese dogs and 10 healthy control dogs, and each exon of the SERT gene was amplified via polymerase chain reaction. The resulting genetic sequences were aligned and analyzed for variations by comparing with reference sequences; the predicted secondary structures of these variations were modeled and cross-verified by applying computational methods. Genetic variations, including five nonsynonymous genetic variations, were detected in five exons. Protein structure and function of the fiv

SUBMITTER: Lee CM 

PROVIDER: S-EPMC5799389 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature