Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.

ABSTRACT: The cerebral cortex is essential for integration and processing of information that is required for most behaviors. The exquisitely precise laminar organization of the cerebral cortex arises during embryonic development when neurons migrate successively from ventricular zones to coalesce into specific cortical layers. While radial glia act as guide rails for projection neuron migration, pre-formed vascular networks provide support and guidance cues for GABAergic interneuron migration. This study provides novel conceptual and mechanistic insights into this paradigm of vascular-neuronal interactions, revealing new mechanisms of GABA and its receptor-mediated signaling via embryonic forebrain endothelial cells. With the use of two new endothelial cell specific conditional mouse models of the

SUBMITTER: Li S 

PROVIDER: S-EPMC5799810 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature