Genetic testing for indeterminate thyroid cytology: review and meta-analysis.

ABSTRACT: Thyroid cancer is the most frequent endocrine malignancy, and its incidence is increasing. A current limitation of cytological evaluation of thyroid nodules is that 20-25% are reported as indeterminate. Therefore, an important challenge for clinicians is to determine whether an indeterminate nodule is malignant, and should undergo surgery, or benign, and should be recommended to follow-up. The emergence of precision medicine has offered a valuable solution for this problem, with four tests currently available for the molecular diagnosis of indeterminate cytologies. However, efforts to critically analyze the quality of the accumulated evidence are scarce. This systematic review and meta-analysis is aimed to contribute to a better knowledge about the four available molecular tests, their tec

SUBMITTER: Vargas-Salas S 

PROVIDER: S-EPMC5799829 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature