Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium.

ABSTRACT: Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly important role in chemical and biochemical analysis. Here we extend this technique to ion-selective photoacoustic optodes (ISPAOs) that serve at the same time as fluorescence-based ISOs, and apply it specifically to potassium (K⁺). Notably, the potassium ion is one of the most abundant cations in biological systems, involved in numerous physiological and pathological processes. Furthermore, it has been recently reported that the presence of abnormal extracellular potassium concentrations in tumors suppresses the immune responses and thus suppresses immunotherapy. However, unfortunately, sensors capable of providing potassium images in vivo are still a future proposition. Her

SUBMITTER: Lee CH 

PROVIDER: S-EPMC5799881 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature