XenoGI: reconstructing the history of genomic island insertions in clades of closely related bacteria.

ABSTRACT:

Background

Genomic islands play an important role in microbial genome evolution, providing a mechanism for strains to adapt to new ecological conditions. A variety of computational methods, both genome-composition based and comparative, have been developed to identify them. Some of these methods are explicitly designed to work in single strains, while others make use of multiple strains. In general, existing methods do not identify islands in the context of the phylogeny in which they evolved. Even multiple strain approaches are best suited to identifying genomic islands that are present in one strain but absent in others. They do not automatically recognize islands which are shared between some strains in the clade or determine the branch on which these islands inserted within the

SUBMITTER: Bush EC 

PROVIDER: S-EPMC5799925 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature