Systematic prediction of DNA shape changes due to CpG methylation explains epigenetic effects on protein-DNA binding.

ABSTRACT:

Background

DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein-DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine methylation, the most frequent modification, represents the addition of a methyl group at the major groove edge of the cytosine base. In mammalian genomes, cytosine methylation most frequently occurs at CpG dinucleotides. In addition to changing the chemical signature of C/G base pairs, cytosine methylation can affect DNA structure. Since the original discovery of DNA methylation, major efforts have been made to understand its effect from a sequence perspective. Compared to unmethylated DNA, however, little structural information is available for methylated DNA, due to

SUBMITTER: Rao S 

PROVIDER: S-EPMC5800008 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature