Assessment of the gorilla gut virome in association with natural simian immunodeficiency virus infection.

ABSTRACT: BACKGROUND:Simian immunodeficiency viruses (SIVs) of chimpanzees and gorillas from Central Africa crossed the species barrier at least four times giving rise to human immunodeficiency virus type 1 (HIV-1) groups M, N, O and P. The paradigm of non-pathogenic lentiviral infections has been challenged by observations of naturally infected chimpanzees with SIVcpz associated with a negative impact on their life span and reproduction, CD4+ T-lymphocyte loss and lymphoid tissue destruction. With the advent and dissemination of new generation sequencing technologies, novel promising markers of immune deficiency have been explored in human and nonhuman primate species, showing changes in the microbiome (dysbiosis) that might be associated with pathogenic conditions. The aim of the present study was

SUBMITTER: D'arc M 

PROVIDER: S-EPMC5800045 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature