Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.

ABSTRACT:

Background

Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood vessels embedded in fetal stroma tissue, lined by trophoblastic cells and organized into chorionic villi (CV) structures.

Methods

We comprehensively characterized human MSC collected from postnatal human chorionic villi of placenta (CV-MSC) by analyzing their growth and proliferation potential, differentiation, immunophenotype, extracellular matrix production, telomere length, aging phenotype, and plasticity.

Results

Immunophenotypic characterization of CV-MSC confirmed the typical MSC marker expression as defined by the International Society for Cellu

SUBMITTER: Ventura Ferreira MS 

PROVIDER: S-EPMC5800083 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature