A genome-wide association study of corneal astigmatism: The CREAM Consortium.

ABSTRACT:

Purpose

To identify genes and genetic markers associated with corneal astigmatism.

Methods

A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and the spherical equivalent were calculated for Europeans using LD score regression.

Results

The meta-analysis of

SUBMITTER: Shah RL 

PROVIDER: S-EPMC5800430 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature