Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is the leading cause of central visual loss among patients over the age of 55 years worldwide. Neovascular-type AMD (nAMD) accounts for approximately 10% of patients with AMD and is characterized by choroidal neovascularization (CNV). The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. This study intends to reveal the expression and functions of YAP during the CNV process.

Methods

In the study, a mouse CNV model was generated by laser photocoagulation. YAP expressio

SUBMITTER: Yan Z 

PROVIDER: S-EPMC5800432 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature