Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy.

ABSTRACT: Natural killer (NK) cells are potential effector cells in cell-based cancer immunotherapy, particularly in the control of hematological malignancies. The chimeric antigen receptor (CAR) is an artificially modified fusion protein that consists of an extracellular antigen recognition domain fused to an intracellular signaling domain. T cells genetically modified with a CAR have demonstrated remarkable success in the treatment of hematological cancers. Compared to T cells, CAR-transduced NK cells (CAR-NK) exhibit several advantages, such as safety in clinical use, the mechanisms by which they recognize cancer cells, and their abundance in clinical samples. Human primary NK cells and the NK-92 cell line have been successfully transduced to express CARs against both hematological cancers and so

SUBMITTER: Hu Y 

PROVIDER: S-EPMC5800464 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature