Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients.

ABSTRACT: Vancomycin, a glycopeptide antibiotic for the treatment of grampositive infections, is mainly eliminated via glomerular filtration. Thus, its therapeutic effects are affected predominantly by renal function. The aim of this study was to develop a population pharmacokinetic model of vancomycin for Chinese adult patients and to investigate the influence of different renal function descriptors on the predictability of the model. A retrospective analysis was performed based on the blood concentrations of vancomycin in 218 Chinese adult patients. Among these patients, the data from 160 were used to establish the population pharmacokinetic model, and the data from the remaining 58 patients were used for external model validation. A simulation was employed to determine the appropriate initial van

SUBMITTER: Ji XW 

PROVIDER: S-EPMC5800467 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature