A new pathological scoring system by the Japanese classification to predict renal outcome in diabetic nephropathy.

ABSTRACT:

Background and objectives

The impact of the newly proposed pathological classification by the Japan Renal Pathology Society (JRPS) on renal outcome is unclear. So we evaluated that impact and created a new pathological scoring to predict outcome using this classification.

Design, setting, participants, & measurements

A multicenter cohort of 493 biopsy-proven Japanese patients with diabetic nephropathy (DN) were analyzed. The association between each pathological factor-Tervaert' and JRPS classifications-and renal outcome (dialysis initiation or 50% eGFR decline) was estimated by adjusted Cox regression. The overall pathological risk score (J-score) was calculated, whereupon its predictive ability for 10-year risk of renal outcome was evaluated.

Results

The J-scores of

SUBMITTER: Hoshino J 

PROVIDER: S-EPMC5800536 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature