Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.

ABSTRACT: HIV-1 envelope glycoprotein (Env) mediates virus attachment and entry into the host cells. Like other membrane-bound and secreted proteins, HIV-1 Env contains at its N terminus a signal peptide (SP) that directs the nascent Env to the endoplasmic reticulum (ER) where Env synthesis and post-translational modifications take place. SP is cleaved during Env biosynthesis but potentially influences the phenotypic traits of the Env protein. The Env SP sequences of HIV-1 isolates display high sequence variability, and the significance of such variability is unclear. We postulate that changes in the Env SP influence Env transport through the ER-Golgi secretory pathway and Env folding and/or glycosylation that impact on Env incorporation into virions, receptor binding and antibody recognition. We fi

SUBMITTER: Upadhyay C 

PROVIDER: S-EPMC5800646 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature