Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses.

ABSTRACT: Annual influenza vaccinations are currently recommended for all individuals 6 months and older. Antibodies induced by vaccination are an important mechanism of protection against infection. Despite the overall public health success of influenza vaccination, many individuals fail to induce a substantial antibody response. Systems-level immune profiling studies have discerned associations between transcriptional and cell subset signatures with the success of antibody responses. However, existing signatures have relied on small cohorts and have not been validated in large independent studies. We leveraged multiple influenza vaccination cohorts spanning distinct geographical locations and seasons from the Human Immunology Project Consortium (HIPC) and the Center for Human Immunology (CHI) to i

SUBMITTER: HIPC-CHI Signatures Project Team 

PROVIDER: S-EPMC5800877 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature