Dataset Information

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

ABSTRACT:

Background

Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule inhibitors that block the interaction between CD40 and tumor necrosis factor receptor-associated factor (TRAF) 6 (TRAF-STOPs), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.

Objectives

This study evaluates the potential of TRAF-STOP treatment in atherosclerosis.

Methods

The effects of TRAF-STOPs on atherosclerosis were investigated in apolipoprotein E deficient (Apoe^-/-) mice. Recombinant high-density lipoprotein (rHDL) nanoparticles were used to target TRAF-STOPs to macrophages.