Oncogene c-Myc promotes epitranscriptome m⁶A reader YTHDF1 expression in colorectal cancer.

ABSTRACT: Recent studies that have emerged on the diversity of RNA modification in tumors suggest their eligibility as bona fide targets in diagnosis and drug discovery. N6-methyladenosine (m⁶A) was first reported and is most common in epitranscriptome modification of various RNAs. The YT521-B homology (YTH) domain family are representative m6A-binding proteins, but how the YTH domain family is involved in cancer remains to be clearly understood. Given that clinical sequence data in colorectal cancer indicate that overexpression of YTHDF1 is outstanding among other family members, we studied the role of Ythdf1 and the transcriptional control of YTHDF1. Immunostaining of Ythdf1 showed that its expression was associated with various malignant tumor behaviors, such as depth, lymph node metas

SUBMITTER: Nishizawa Y 

PROVIDER: S-EPMC5800917 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature