Association between PD-L1 expression and driver gene status in non-small-cell lung cancer: a meta-analysis.

ABSTRACT:

Objective

To assess the association between PD-L1 expression and driver gene mutations in patients with non-small-cell lung cancer (NSCLC).

Method

We performed a meta-analysis of 26 studies (7541 patients) which were published from 2015 to 2017. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated to describe the correlation. Subgroup analysis was performed based on population characteristics, types of PD-L1 antibodies and quality of individual studies.

Results

A lower frequency of PD-L1 positivity was observed in NSCLCs harboring EGFR mutation (OR: 0.64, 95% CI, 0.45-0.91, p = 0.014). A negative correlation was also found at 1% (OR: 0.35, 95% CI, 0.22-0.55, p = 0.000) and 50% (OR: 0.33, 95% CI, 0.14-0.81, p = 0.015) cutoff

SUBMITTER: Lan B 

PROVIDER: S-EPMC5800936 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature