Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer.

ABSTRACT:

Introduction

To evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer (PCa).

Methods

We included men with localized PCa treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) of escalated dose (≥74 Gy in 1.8 or 2 Gy fractions) between 1992 and 2013 at an NCI-designated cancer centre. Men receiving androgen deprivation therapy were excluded. The non-treatment day ratio (NTDR) was defined as the number of non-treatment days divided by the total elapsed days of therapy. NTDR was analysed for each National Comprehensive Cancer Network (NCCN) risk group.

Results

There were 1728 men included (839 low-risk, 776 intermediate-risk and 113 high-risk), with a medi

SUBMITTER: Dong Y 

PROVIDER: S-EPMC5800942 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature