Project description:Focused on the cytochromes P450 (CYPs), we studied gene expression changes in mice treated with acyclic nucleoside antivirals adefovir and tenofovir. Positive control group was treated by prototypic CYP inducers phenobarbital and beta-naphthoflavone. Expression profiling with Steroltalk cDNA arrays revealed major changes in CYP mRNA expression in the inducers-treated group but only minor changes in CYP expression in the adefovir and tenofovir groups.

2014-06-03 | GSE47698 | GEO

Synthesis of some novel hydrazono acyclic nucleoside analogues.

Project description: Not available

| S-EPMC2887276 | biostudies-literature

Non-productive infection of glial cells with SARS-CoV-2 in hamster organotypic cerebellar slice cultures

Project description:The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice culture to determine the permissivity of hamster brain tissues to SARS-CoV-2 infection. We found levels of live virus waned after inoculation and observed no evidence of cell-to-cell spread, indicating that SARS-CoV-2 infection was non-productive. Nonetheless, we identified a small number of infected cells with glial phenotypes; yet no evidence of viral infection or replication was observed in neurons. Our data corroborates several clinical studies that have assessed patients with COVID-19 and their association with neurological involvement.

2022-05-06 | GSE201921 | GEO

Structure of cyclic nucleoside phosphonate ester prodrugs: an inquiry.

Project description: Not available

| S-EPMC3254244 | biostudies-literature