Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress.

ABSTRACT: Neural circuits via which stress leads to disruptions in fear extinction is often explored in animal stress models. Using the single prolonged stress (SPS) model of post traumatic stress disorder and the immediate early gene (IEG) c-Fos as a measure of neural activity, we previously identified patterns of neural activity through which SPS disrupts extinction retention. However, none of these stress effects were specific to fear or extinction learning and memory. C-Jun is another IEG that is sometimes regulated in a different manner to c-Fos and could be used to identify emotional learning/memory specific patterns of neural activity that are sensitive to SPS. Animals were either fear conditioned (CS-fear) or presented with CSs only (CS-only) then subjected to extinction training and testing

SUBMITTER: Knox D 

PROVIDER: S-EPMC5800954 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature