A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.

ABSTRACT:

Background

Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs), small non-coding RNAs that post-transcriptionally regulate target genes. MiR-125b-5p is downregulated in patients with end-stage dilated and ischemic cardiomyopathy, and has been proposed as a biomarker of heart failure. We previously reported that the β-blocker carvedilol promotes cardioprotection via β-arrestin-biased agonism of β₁-adrenergic receptor while stimulating miR-125b-5p processing in the mouse heart. We hypothesize that β₁-adrenergic receptor/β-arrestin1-responsive miR-125b-5p confers the improvement of cardiac function and structure after acute myocardial infarction.

Methods and results

Using cultured cardiomyocyte (CM) and in vivo approaches

SUBMITTER: Bayoumi AS 

PROVIDER: S-EPMC5800989 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature