Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.

ABSTRACT: The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to

SUBMITTER: Kragel PA 

PROVIDER: S-EPMC5801068 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature