Estimating global treatment toxicity burden from adverse-event data.

ABSTRACT:

Background

A summary measure that reflects the global toxicity burden of a treatment is essential for comparing therapies. Current toxicity summaries are ad hoc and do not distinguish among the severities and types of toxicities. Here a clinically feasible method for estimating the toxicity burden, based on a prospective evaluation of the toxicity profile of a randomized clinical trial of 746 prostate cancer patients conducted by SWOG, is proposed.

Methods

For 308 patients who experienced severe toxicities, 2 physicians randomly selected from 14 physicians evaluated each toxicity profile and assigned a visual analogue scale score (0-10) based on their impression of the global burden of toxicities. With mixed-effects models, severity scores and a 10-point toxicity burden scor

SUBMITTER: Lee SM 

PROVIDER: S-EPMC5801103 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature