Effects of isolated tobacco alkaloids and tobacco products on deprivation-induced food intake and meal patterns in rats.

ABSTRACT: The ability of smoking to reduce body weight serves as motivation for continued smoking. It is unclear to what extent non-nicotine constituents in cigarettes are contributing to the weight-reducing effect of smoking. The purpose of the current study was to examine the effects of nicotine and four minor tobacco alkaloids (nornicotine, cotinine, anatabine, and anabasine) on food intake, one of the key regulators of body weight. In addition, a smokeless tobacco extract (STE) and e-cigarette (EC) refill liquid were used to model the effects of actual tobacco product exposure on food intake. Male Holztman rats were trained to lever press for food pellets during daily 2h sessions in operant chambers. In Experiment 1, the effects of subcutaneous injections of saline, nicotine (0.25-1.00mg/kg), no

SUBMITTER: Bunney PE 

PROVIDER: S-EPMC5801111 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature