Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years.

ABSTRACT: BACKGROUND:Exposure to perfluoroalkyl substances (PFASs) may impact children's neurodevelopment. OBJECTIVE:To examine the association of prenatal and early childhood serum PFAS concentrations with children's reading skills at ages 5 and 8years. METHODS:We used data from 167 mother-child pairs recruited during pregnancy (2003-2006) in Cincinnati, OH, quantified prenatal serum PFAS concentrations at 16±3weeks of gestation and childhood sera at ages 3 and 8years. We assessed children's reading skills using Woodcock-Johnson Tests of Achievement III at age 5years and Wide Range Achievement Test-4 at age 8years. We used general linear regression to quantify the covariate-adjusted associations between natural log-transformed PFAS concentrations and reading skills, and used multiple informant mode

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5801149 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature