Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population.

ABSTRACT: Humans respond to chemical exposures differently due to many factors, such as previous and concurrent stressors, age, sex, and genetic background. The vast majority of laboratory-based toxicology studies, however, have not considered the impact of population-level variability within dose-response relationships. The lack of data dealing with the influence of genetic diversity on the response to chemical exposure provides a difficult challenge for risk assessment as individuals within the population will display a wide-range of responses following toxicant challenge. Notably, the genetic background of individuals plays a major role in the variability seen in a population-level response to a drug or chemical and, thus, there is growing interest in including genetic diversity into laboratory-m

SUBMITTER: Dornbos P 

PROVIDER: S-EPMC5801153 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature