Maximum likelihood estimation of influenza vaccine effectiveness against transmission from the household and from the community.

ABSTRACT: Influenza vaccination is recommended as the best way to protect against influenza infection and illness. Due to seasonal changes in influenza virus types and subtypes, a new vaccine must be produced, and vaccine effectiveness (VE) must be estimated, annually. Since 2010, influenza vaccination has been recommended universally in the United States, making randomized clinical trials unethical. Recent studies have used a monitored household cohort study design to determine separate VE estimates against influenza transmission from the household and community. We developed a probability model and accompanying maximum likelihood procedure to estimate vaccine-related protection against transmission of influenza from the household and the community. Using agent-based stochastic simulations, we vali

SUBMITTER: Ainslie KEC 

PROVIDER: S-EPMC5801170 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature