The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.

ABSTRACT: Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914-an immunoproteasome-specific inhibitor-as highly protective during severe heart disease. Represented by reduced heart infiltration of monocytes/macrophages and diminished organ damage, ONX 0914 treatment reversed fulminant pathology. Virus-induced immune response features like overwhelming pro-inflammatory cytokine and chemokine production as well as a progressive loss of lymphocytes all being reminiscent

SUBMITTER: Althof N 

PROVIDER: S-EPMC5801517 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature