Unearthing new genomic markers of drug response by improved measurement of discriminative power.

ABSTRACT: BACKGROUND:Oncology drugs are only effective in a small proportion of cancer patients. Our current ability to identify these responsive patients before treatment is still poor in most cases. Thus, there is a pressing need to discover response markers for marketed and research oncology drugs. Screening these drugs against a large panel of cancer cell lines has led to the discovery of new genomic markers of in vitro drug response. However, while the identification of such markers among thousands of candidate drug-gene associations in the data is error-prone, an appraisal of the effectiveness of such detection task is currently lacking. METHODS:Here we present a new non-parametric method to measuring the discriminative power of a drug-gene association. Unlike parametric statistical tests, the

SUBMITTER: Dang CC 

PROVIDER: S-EPMC5801688 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature