Landmarks in Existing Tissue at Wounds Are Utilized to Generate Pattern in Regenerating Tissue.

ABSTRACT: Regeneration in many organisms involves the formation of a blastema, which differentiates and organizes into the appropriate missing tissues. How blastema pattern is generated and integrated with pre-existing tissues is a central question in the field of regeneration. Planarians are free-living flatworms capable of rapidly regenerating from small body fragments [1]. A cell cluster at the anterior tip of planarian head blastemas (the anterior pole) is required for anterior-posterior (AP) and medial-lateral (ML) blastema patterning [2-4]. Transplantation of the head tip into tails induced host tissues to grow patterned head-like outgrowths containing a midline. Given the important patterning role of the anterior pole, understanding how it becomes localized during regeneration would help expl

SUBMITTER: Oderberg IM 

PROVIDER: S-EPMC5801735 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature