[¹¹ C]Fluoroform, a Breakthrough for Versatile Labeling of PET Radiotracer Trifluoromethyl Groups in High Molar Activity.

ABSTRACT: Positron-emission tomography (PET) is an immensely important imaging modality in biomedical research and drug development but must use selective radiotracers to achieve biochemical specificity. Such radiotracers are usually labeled with carbon-11 (t_1/2 =20 min) or fluorine-18 (t_1/2 =110 min), but these are only available from cyclotrons in a few simple chemical forms. [¹⁸ F]Fluoroform has emerged for labeling tracers in trifluoromethyl groups but is severely limited in utility by low radioactivity per mass (low molar activity). Here, the synthesis of [¹¹ C]fluoroform is described, based on CoF₃ -mediated fluorination of cyclotron-produced [¹¹ C]methane. This process is efficient and repetitively reliable. [¹¹ C]Fl

SUBMITTER: Haskali MB 

PROVIDER: S-EPMC5801743 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature