MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer.

ABSTRACT: Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate-limiting component for telomerase activity, increasing evidence suggests an important role for the regulation of TERC in telomere maintenance and perhaps other functions in human cancer. By using three orthogonal methods including RNAseq, RT-qPCR, and an analytically validated chromogenic RNA in situ hybridization assay, we report consistent overexpression of TERC in prostate cancer. This overexpression occurs at the precursor stage (e.g. high-grade prostatic intraepithelial neoplasia or PIN) and persists throughout all stages of disease progression. L

SUBMITTER: Baena-Del Valle JA 

PROVIDER: S-EPMC5801764 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature