A three-lncRNA signature predicts overall survival and disease-free survival in patients with esophageal squamous cell carcinoma.

ABSTRACT:

Background

Increasing evidence shows that dysregulated long non-coding RNAs (lncRNAs) can serve as potential biomarkers for cancer prognosis. However, lncRNA signatures, as potential prognostic biomarkers for esophageal squamous cell carcinoma (ESCC), have been seldom reported.

Methods

Based on our previous transcriptome RNA sequencing analysis from 15 paired ESCC tissues and adjacent normal tissues, we selected 10 lncRNAs with high score rank and characterized the expression of those lncRNAs, by qRT-PCR, in 138 ESCC and paired adjacent normal samples. These 138 patients were divided randomly into training (n = 77) and test (n = 59) groups. A prognostic signature of lncRNAs was identified in the training group and validated in the test group and in an independent cohort (n =

SUBMITTER: Huang GW 

PROVIDER: S-EPMC5801805 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature