The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

Methods

The TOPICAL study was a 4-period, partially-randomised, controlled, crossover study to investigate four aerosolised approaches in IPF subjects. Nine subjects were randomised to receive ^99mTechnetium-labelled monodisperse salbutamol (1.5 μm or 6 μm; periods 1 and 2). Subjects also received radio-labelled salbutamol using a polydisperse nebuliser (period 3) and unlabelled salbutamol (400 μg) using a polydisperse pressurized metered dose inhaler with volumatic spacer (pMDI; period 4).

Results

Small monodisperse particles (1.5 μm) achieved significantly better total lung deposition (TLD, mean % ± SD) than larger part

SUBMITTER: Usmani OS 

PROVIDER: S-EPMC5801831 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature