Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

ABSTRACT:

Background

Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment.

Methods

Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The drugga

SUBMITTER: Vasaikar S 

PROVIDER: S-EPMC5801893 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature