Biological activities of frankincense essential oil in human dermal fibroblasts.

ABSTRACT: Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. FREO exhibited robust anti-proliferative activity in these skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1. We also studied its effect in regulating genome-wide gene expression. FREO robustly modulated global gene expression. Furthermore, Ingenuity^® Pathway Analysis showed that FREO affected many

SUBMITTER: Han X 

PROVIDER: S-EPMC5801908 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature